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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
The dosage may vary and is titrated to effect, with some guidelines recommending initial treatment with a low dose. [32] Methylphenidate is available in both immediate-release and extended-release (XR) formulations to provide a sustained release of the drug. [33] [34] Methylphenidate is not approved for children under six years of age. [35] [36]
Repeated administration of a medication is also different from single dosing, as many drugs have active metabolites that can build up in the body. [6] Patient variables such as sex, age, and organ function may also influence the effect of the drug on the system. These variables are rarely included in equianalgesic charts. [7] [3] [8]
CMV is really common—more than half of adults have been infected with it by age 40, according to the Centers for Disease Control and Prevention (CDC). Most people with CMV show no symptoms, but ...
Officials say two migrant teens were victims in a New York City stabbing, one fatally, after the teens were asked if they spoke English and they responded that they didn't. Police say they were ...
The formula for determining the dose is: [1] If there is a single recommended maintenance dose in the literature, this is preferred. If there are a range of recommended maintenance doses then If the literature recommends generally increasing from initial to maximum dose provided it is tolerated, pick the maximum dose.
Stepping inside a time capsule. The one-story, nearly-8,000-square-foot fortification is bulwarked by concrete walls 30 inches thick. The two exterior entrances have armored steel blast doors ...
In over-the-counter medicines, both dose and dosage is usually based on age. Typically, different doses are recommended for children 6 years and under, for children aged 6 to 12 years, and for persons 12 years and older, but outside of those ranges the guidance is slim. [2]