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Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by chronic respiratory symptoms and airflow limitation. [8] GOLD 2024 defined COPD as a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea or shortness of breath, cough, sputum production or exacerbations) due to abnormalities of the airways (bronchitis ...
Many people with chronic obstructive pulmonary disease have a low partial pressure of oxygen in the blood and high partial pressure of carbon dioxide.Treatment with supplemental oxygen may improve their well-being; alternatively, in some this can lead to the adverse effect of elevating the carbon dioxide content in the blood (hypercapnia) to levels that may become toxic.
In severe cases that are difficult to control, chronic treatment with oral corticosteroids may be necessary, although this is fraught with significant side effects. COPD is generally irreversible although lung function can partially recover if the patient stops smoking. Smoking cessation is an essential aspect of treatment. [9]
These effects contribute to the pathogenesis of diseases such as acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). In the central nervous system, high levels of oxygen can cause seizures, which are a significant risk in hyperbaric oxygen therapy if not carefully monitored. [ 2 ]
Common (≥1/100 to <1/10) side effects include candidiasis, headache, tremor, palpitations, throat irritation, coughing, and dysphonia. [7] Pneumonia is a common side effect in people with COPD, and other, less common side effects have been documented.
Pulmonary toxicity is the medical name for side effects on the lungs. Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). Other (non-medical) causes of pulmonary toxicity can be chemical compounds and airborne particulate matter.
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