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  2. Interferon - Wikipedia

    en.wikipedia.org/wiki/Interferon

    Interferons (IFNs, / ˌ ɪ n t ər ˈ f ɪər ɒ n / IN-tər-FEER-on [1]) are a group of signaling proteins [2] made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.

  3. Cytokine - Wikipedia

    en.wikipedia.org/wiki/Cytokine

    Interferon-alpha, an interferon type I, was identified in 1957 as a protein that interfered with viral replication. [5] The activity of interferon-gamma (the sole member of the interferon type II class) was described in 1965; this was the first identified lymphocyte-derived mediator. [6]

  4. Interferon type I - Wikipedia

    en.wikipedia.org/wiki/Interferon_type_I

    The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...

  5. Viral interference - Wikipedia

    en.wikipedia.org/wiki/Viral_interference

    Viral interference is considered the most common outcome of coinfection, or the simultaneous infection of a host by two or more distinct viruses. [5] The primary form of viral interference is known as superinfection exclusion, in which the initial infection stimulates a resistance to subsequent infection by related viruses.

  6. Viral strategies for immune response evasion - Wikipedia

    en.wikipedia.org/wiki/Viral_strategies_for...

    The Interferon System is composed of a family of cytokines. Type-I Interferons, IFN-α/β, and Type-III Interferons, IFN-λ play key roles in adaptive immunity, acting as communication highways between cells infected with foreign double stranded DNA or double stranded RNA.

  7. Innate immune system - Wikipedia

    en.wikipedia.org/wiki/Innate_immune_system

    Innate immune system cells prevent free growth of microorganisms within the body, but many pathogens have evolved mechanisms to evade it. [ 21 ] [ 22 ] One strategy is intracellular replication, as practised by Mycobacterium tuberculosis , or wearing a protective capsule, which prevents lysis by complement and by phagocytes, as in Salmonella ...

  8. Interferome - Wikipedia

    en.wikipedia.org/wiki/Interferome

    These interferons regulate the transcription of approximately 2000 genes in an interferon subtype, dose, cell type and stimulus dependent manner. This database of interferon regulated genes is an attempt at integrating information from high-throughput experiments and molecular biology databases to gain a detailed understanding of interferon ...

  9. IFNA2 - Wikipedia

    en.wikipedia.org/wiki/IFNA2

    3440 15965 Ensembl ENSG00000188379 ENSMUSG00000078354 UniProt P01563 P01573 RefSeq (mRNA) NM_000605 NM_010503 RefSeq (protein) NP_000596 NP_034633 Location (UCSC) Chr 9: 21.38 – 21.39 Mb Chr 4: 88.6 – 88.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Protein family Human interferon alpha-2 (IFNα2) is ...