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The 1972 edition of the Physicians' Desk Reference lists Obetrol containing (10 mg tablet): 2.5 mg methamphetamine saccharate; 2.5 mg methamphetamine hydrochloride; 2.5 mg racemic amphetamine sulfate; 2.5 mg dextroamphetamine sulfate; Obetrol was also available in 20 mg tablets which contained twice the quantity of its ingredients, in the same ...
The oral bioavailability of amphetamine varies with gastrointestinal pH; [20] it is well absorbed from the gut, and bioavailability is typically 90%. [10] Amphetamine is a weak base with a p K a of 9.9; [ 186 ] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid ...
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Starting Jan. 1, older adults on Medicare will spend no more than $2,000 a year on prescription drugs when a new price cap on out-of-pocket payments from the Inflation Reduction Act goes into effect.
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At doses under 20 mg/day, selegiline is a selective and irreversible inhibitor of monoamine oxidase B (MAO-B), increasing levels of dopamine in the brain. In clinical trials, Selegiline has been used in the treatment of attention deficit hyperactivity disorder (ADHD). [ 104 ]
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To avoid toxicity and risk of side effects, FDA guidelines recommend an initial dose of methamphetamine at doses 5–10 mg/day for ADHD in adults and children over six years of age, and may be increased at weekly intervals of 5 mg, up to 25 mg/day, until optimum clinical response is found; the usual effective dose is around 20–25 mg/day.
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