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Furthermore, anti-histone antibodies can also be positive in drug-induced lupus. [citation needed] Anti-Histone antibodies are positive in up to 95% of patients with drug induced lupus. The most common medications associated with drug induced lupus are hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. [9]
Hydralazine is within the top three drugs that is known to induce systemic lupus and this adverse drug event is dose dependent yet significant. Very common (>10% frequency) side effects include headache, tachycardia, and palpitations .
Patients with drug-induced lupus erythematosus typically have positive tests for anti-histone antibodies but do not have indications for anti-dsDNA antibodies. Patients with idiopathic systemic lupus erythematosus have both types of autoantibodies present in their blood. Thus, this test can be useful in distinguishing these two illnesses. [9]
DR4 is associated with extraarticular [2] rheumatoid arthritis, [3] hydralazine-induced female systemic lupus erythematosus, [4] pemphigoid gestationis, [5] pemphigus foliaceus, [6] obstructive hypertrophic cardiomyopathy, [7] IgA nephropathy, [8] 'shared syndrome'-systemic sclerosis/rheumatoid arthritis [9] and polymyalgia rheumatica. [10]
There are also a few types of medications, including certain antibiotics as well as seizure, anti-inflammatory and blood pressure treatments, that can trigger drug-induced lupus erythematosus, or ...
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Drug-induced lupus erythematosus is a (generally) reversible condition that usually occurs in people being treated for a long-term illness. Drug-induced lupus mimics SLE. However, symptoms of drug-induced lupus generally disappear once the medication that triggered the episode is stopped.
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