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The particles are considered interfering when they affect the function of the parent virus through competitive inhibition [4] during coinfection. In other words, defective and non-defective viruses replicate simultaneously, but when defective particles increase, the amount of replicated non-defective virus is decreased.
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The von Magnus phenomenon describes the generation of defective interfering particles (DIPs) by viruses. [1] It was first observed by Preben von Magnus in influenza viruses, [2] after the serial passage of undiluted allantoic fluid in eggs. [3]
TIPs are built off the phenomenon of defective interfering particles (DIPs) discovered by Preben Von Magnus in the early 1950s, during his work on influenza viruses. [21] [22] [23] [2] DIPs are spontaneously arising virus mutants, first described by von Magnus as "incomplete" viruses, in which a critical portion of the viral genome has been lost.
Defective interfering particles are defective viruses that have lost their ability to replicate except in the presence of a helper virus, which is normally the parental virus. They can also interfere with the helper virus. Defective interfering particles (RNA) Defective interfering particles (DNA)
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Despite the inability to isolate them, von Magnus discovered defective interfering particles (DIPs) using the "influenza virus system". He called them "incomplete" or "immature". [9] He found that when viruses were expanded at high doses, "incomplete viruses" or "particles" were produced and that these interfered with viral replication. This ...
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