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Phenylglycine is the organic compound with the formula C 6 H 5 CH(NH 2)CO 2 H. It is a non-proteinogenic alpha amino acid related to alanine, but with a phenyl group in place of the methyl group. It is a white solid. The compound exhibits some biological activity. [1]
[2] [3] Upon treatment with base, the salt converts to glycine methyl ester. [4] Glycine methyl ester (and other esters of glycine) are not shelf-stable, tending to polymerize when stored at room temperature [4] or convert to diketopiperazine. The hydrochloride is shelf-stable.
2 H 3 N + CH 2 COO − → H 3 N + CH 2 CONHCH 2 COO − + H 2 O. Pyrolysis of glycine or glycylglycine gives 2,5-diketopiperazine, the cyclic diamide. [35] Glycine forms esters with alcohols. They are often isolated as their hydrochloride, such as glycine methyl ester hydrochloride. Otherwise, the free ester tends to convert to diketopiperazine.
Biosynthesis of HPG. HPG is synthesized from prephenate, an intermediate in the shikimic acid pathway and also a precursor to tyrosine.Prephenate is aromatized by prephenate dehydrogenase (Pdh) using NAD + as a cofactor to produce 4-hydroxyphenylpyruvate. 4-Hydroxyphenylpyruvate is then oxidized by 4-hydroxymandelate synthase (4HmaS) using oxygen to form 4-hydroxymandelate and hydrogen ...
D. Daclatasvir; Damascenine; 4,21-Dehydrogeissoschizine; Dehydrosecodine; Demephion; Demeton-S-methyl; Desacetoxyvindoline; Deserpidine; Dexmethylphenidate; 3,4 ...
Glycol ethers are designated "E-series" or "P-series" for those made from ethylene oxide or propylene oxide, respectively.Typically, E-series glycol ethers are found in pharmaceuticals, sunscreens, cosmetics, inks, dyes and water-based paints, while P-series glycol ethers are used in degreasers, cleaners, aerosol paints and adhesives.
Doses up to 200 mg/kg are not observed to have stimulant properties, and a dosage of 20 mg/kg does not potentiate the effects of dextroamphetamine in rats. [1] It displays possible cholinergic properties, and potentiates dopamine while partially inhibiting serotonin. [1] PRL-8-53 reverses the catatonic and ptotic effects of reserpine. [1] [3]
[1] [2] Azlactone chemistry: step 2 is a Perkin variation. Hippuric acid, the benzamide derivative of glycine, cyclizes in the presence of acetic anhydride, condensing to give 2-phenyl-oxazolone. [3] This intermediate also has two acidic protons and reacts with benzaldehyde, acetic anhydride and sodium acetate to a so-called azlactone.