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Antidepressants can greatly magnify the effects of alcohol, creating more central nervous system depression, increasing sedation and further impairing your judgment, reaction times and coordination.
As an SSRI antidepressant, escitalopram is commonly prescribed to treat depression. The FDA also approves it for the treatment of generalized anxiety disorder (GAD).
Antidepressants affect variable neuronal receptors such as muscarinic cholinergic, α 1 - and α 2-adrenergic, H 1-histaminergic, and sodium channels in the cardiac muscle, leading to decreased cardiac conduction and cardiotoxicity associated particularly with TCAs, and to a lesser extent with SSRIs. [26]
Most of the weight gain caused by antidepressants is mild, with a 2017 study from Australia finding that high-dosage antidepressant users gain 0.28kg (about 0.6 lbs) per year on average.
Antidepressants are defined by their effect on mood, not on general brain activity, so they form an orthogonal category of drugs. Depressants are closely related to sedatives as a category of drugs, with significant overlap. The terms may sometimes be used interchangeably or may be used in somewhat different contexts. [citation needed]
SSRIs are beneficial in both acute response and long-term maintenance treatment for both depression and anxiety disorder. [ 16 ] SSRIs can increase anxiety initially due to negative feedback through the serotonergic autoreceptors ; for this reason a concurrent benzodiazepine can be used until the anxiolytic effect of the SSRI occurs.
St John's wort, [87] most non-SSRI antidepressants such as amoxapine, atomoxetine, bupropion, venlafaxine, quetiapine, the tricyclics, methylphenidate, SNRIs such as duloxetine, venlafaxine, cocaine, tramadol, and certain TAAR1 agonists like amphetamine, phenethylamine, methamphetamine. Norepinephrine releasing agents
In addition to SSRIs, several other types of antidepressants are commonly prescribed to treat depression. These include: ... oxazepam is used to treat anxiety and certain symptoms of alcohol ...
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