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In adult humans, Ets1 is expressed at high levels mainly in immune tissues such as thymus, spleen, and lymph node (B cells, T cells, NK cells, and NK T cells and non-lymphoid immune cells). An enforced expression of Ets1 blocks differentiation of B- and T-cells. By contrast, knocking Ets1 down causes multiple defects in the immune system.
Cell mechanics is a sub-field of biophysics that focuses on the mechanical properties and behavior of living cells and how it relates to cell function. [1] It encompasses aspects of cell biophysics , biomechanics , soft matter physics and rheology , mechanobiology and cell biology .
The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis. Multiple ETS factors have been found to be associated with cancer, such as through gene fusion.
Cells are incubated onto a flexible silicone sheet substrate. The cells then apply force onto the sheets causing a wrinkling pattern and is analyzed through the number of wrinkles and patterns. The downside to this method is the difficulty in transforming the patterns into a traction force map leading to potential inaccuracy in identifying ...
Cell biophysics (or cellular biophysics) is a sub-field of biophysics that focuses on physical principles underlying cell function. Sub-areas of current interest include statistical models of intracellular signaling dynamics, intracellular transport, cell mechanics (including membrane and cytoskeletal mechanics), molecular motors, biological electricity and genetic network theory.
ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. [5] Elk-1 functions as a transcription activator . It is classified as a ternary complex factor (TCF), a subclass of the ETS family , which is characterized by a common protein domain that regulates DNA binding to target sequences.
Mechanobiology is an emerging field of science at the interface of biology, engineering, chemistry and physics. It focuses on how physical forces and changes in the mechanical properties of cells and tissues contribute to development, cell differentiation, physiology, and disease.
Structural Biochemistry/Cell Organelles/Animal Cell; An Introduction to Molecular Biology/Macromolecules and Cells; Principles of Biochemistry/Cell and its Biochemistry; Biomedical Engineering Theory And Practice/Biomechanics; Organelles/Nucleus; Cell Biology/Organelles/Nucleus; Structural Biochemistry/Volume 2; Science: An Elementary Teacher ...