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The common dose is 2 g intravenously every 12 hours and the high dose, notably in critically ill patients, is 2g every 8 hours. Theoretical reasons exist for giving temocillin as a continuous intravenous infusion in severe disease [7] [8] a single loading dose of 2 g is given intravenously followed by a 4-g or 6-g infusion over 24 hours.
Some of these are obsolete; others remain current. There is a risk of serious consequences when abbreviations are misread or misinterpreted. In the United Kingdom, all prescriptions should be in English without abbreviation (apart from some units such as mg and mL; micrograms and nanograms should not be abbreviated). [5]
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
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A drug is considered highly soluble when the highest dose strength is soluble in 250 ml or less of aqueous media over the pH range of 1 to 6.8. The volume estimate of 250 ml is derived from typical bioequivalence study protocols that prescribe administration of a drug product to fasting human volunteers with a glass of water.
The prescription symbol, ℞, as printed on the blister pack of a prescription drug. A prescription, often abbreviated ℞ or Rx, is a formal communication from a physician or other registered healthcare professional to a pharmacist, authorizing them to dispense a specific prescription drug for a specific patient.
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A single 30 gram batch of pure crystalline penicillin G sodium was obtained: this was also stored at Mill Hill. One penicillin unit was defined as 0.5988 micrograms of the Second International Standard. [30] There is an older unit for penicillin V that is not equivalent to the current penicillin V unit.