Search results
Results from the WOW.Com Content Network
Polygalacturonase inhibitor protein found in Phaseolus vulgaris (1OGQ). Residues that interact with PG active site are highlighted in blue. [23] Phytopathogenic fungi expose plant cell walls to cell wall degrading enzymes (CWDEs) like PGs. [4] In response, most plants have natural inhibitor proteins that slow the
Polygalacturonase inhibitor proteins (PGIPs), also known as polygalacturonase-inhibiting proteins, are plant proteins capable of inhibiting the action of polygalacturonase (PG) enzymes produced by bacterial and fungal pathogens. [1] PGs can be produced by pathogens to degrade the polygalacturonan component of plant cell walls. [2]
Echinocandin B. Echinocandins are a class of antifungal drugs [1] that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme 1,3-β glucan synthase.
A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. [ 1 ] A ribosome is a biological machine that utilizes protein dynamics on nanoscales to translate RNA into proteins
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.
UTP—glucose-1-phosphate uridylyltransferase is an enzyme found in all three domains (bacteria, eukarya, and archaea) as it is a key player in glycogenesis and cell wall synthesis. Its role in sugar metabolism has been studied extensively in plants in order to understand plant growth and increase agricultural production.
A plant cell wall was first observed and named (simply as a "wall") by Robert Hooke in 1665. [3] However, "the dead excrusion product of the living protoplast" was forgotten, for almost three centuries, being the subject of scientific interest mainly as a resource for industrial processing or in relation to animal or human health.
[medical citation needed] It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall. [medical citation needed] Caspofungin was the first inhibitor of fungal (1→3)-β-D-glucan synthesis to be approved by the United States Food and Drug Administration. [6]