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Norethisterone, as norethisterone acetate and norethisterone enanthate, has been studied for use as a potential male hormonal contraceptive in combination with testosterone in men. [ 124 ] [ 125 ] Long-acting norethisterone microspheres for intramuscular injection have been studied for potential use in birth control.
NETE is a prodrug of norethisterone in the body. [13] Upon reaching circulation, it is rapidly converted into norethisterone by esterases.Hence, as a prodrug of norethisterone, NETE has essentially the same effects as norethisterone, acting as a potent progestogen with additional weak androgenic and estrogenic activity (the latter via its metabolite ethinylestradiol). [14]
Norethisterone (17β-deacetyl-NETA), the active form of NETA. NETA is a prodrug of norethisterone in the body. [9] Upon oral ingestion, it is rapidly converted into norethisterone by esterases during intestinal and first-pass hepatic metabolism. [10]
In the process, metabolites, or byproducts, of the drug are produced, which can linger in our blood, urine (and even in our hair) for long after the initial effects of the drug are felt.
These include the 19-nortestosterone derivatives norethisterone, noretynodrel, and tibolone, as well as the norethisterone prodrugs [251] norethisterone acetate, norethisterone enanthate, lynestrenol, and etynodiol diacetate. [1] The estrogenic activity of norethisterone and its prodrugs are due to metabolism into ethinylestradiol. [1]
The medication is a prodrug of norelgestromin and to a lesser extent of levonorgestrel in the body. [ 1 ] Norgestimate was patented in 1965 and introduced for medical use, specifically in birth control pills, in 1986.
In other words, your body burns a lot of calories to keep muscle around, so if you’re not actively using it, your body will let it go to conserve energy for more essential functions.
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