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Samuel "Sam" and David Camden are fraternal twin boys and the youngest of the Camden children. They were originally played by all four Brino quadruplets: Lorenzo, Myrinda, Nikolas, and Zachary, but once the quads started aging and showing differences between them, Lorenzo and Nikolas became the official actors for Sam and David.
The series follows Reverend Eric Camden, a Protestant minister living in the fictional town of Glen Oak, California, and his wife Annie as they deal with the drama of raising 7 children (twins Sam and David come later in the series) ranging in age from babies to adults with families of their own.
Eric and Rabbi Glass (Richard Lewis) visit the church to spy on the new associate-pastor (Jeremy London); Ruthie is caught slow-dancing with her boyfriend when she's supposed to be babysitting Sam and David; Lucy asks Simon to dig up some information on Roxanne during his ride-along with her and Kevin in their patrol car; Kevin runs into his ex ...
Matt is upset when Simon wants him to prescribe birth-control pills for him and his new girlfriend, and rumors sweep through the house as the two brothers talk secretly; the previous owner of Lucy and Kevin's new house asks them to sell it back to him; the older Camden kids hide a huge secret about Mary from their parents, who are furious that ...
Meanwhile, Ruthie enlists Lucy's help to convince their mom to let her attend a couples party with Peter; Chandler's mother (Concetta Tomei) pays him an unwelcome visit when he is named executor of his father's estate; an angered Lucy causes a rift when she considers moving; Cecilia teaches Sam and David how to ride bikes.
Stephen Collins as Eric Camden; Catherine Hicks as Annie Camden; Barry Watson as Matt Camden; David Gallagher as Simon Camden; Jessica Biel as Mary Camden; Beverley Mitchell as Lucy Camden; Mackenzie Rosman as Ruthie Camden; Happy as Happy the Dog; Note: Nikolas and Lorenzo Brino portray Sam and David Camden (episodes 14-22), but are uncredited ...
Stephen Collins as Eric Camden; Catherine Hicks as Annie Camden (episodes 1-2, 5-22) Beverley Mitchell as Lucy Camden-Kinkirk; Mackenzie Rosman as Ruthie Camden (16 episodes) Nikolas and Lorenzo Brino as Sam and David Camden; George Stults as Kevin Kinkirk; Tyler Hoechlin as Martin Brewer; Haylie Duff as Sandy Jameson; Happy the Dog as herself
Eric suspects that Ruthie knows something about Matt and Sarah, and he himself wonders if they're married already. Meanwhile, Sam and David get big-boy beds; and an older couple seeks guidance from Eric when their 45-year-old son Jeremiah runs away from home.