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Puberty is considered delayed when the child has not begun puberty when two standard deviations or about 95% of children from similar backgrounds have. [7] [8] [9]In North American girls, puberty is considered delayed when breast development has not begun by age 13, when they have not started menstruating by age 15, [2] and when there is no increased growth rate. [8]
Thelarche, also known as breast budding, is the onset of secondary breast development, often representing the beginning of pubertal development. [1] It is the stage at which male and female breasts differentiate due to variance in hormone levels; however, some males have a condition in which they develop breasts, termed gynecomastia .
Breast development, also known as mammogenesis, is a complex biological process in primates that takes place throughout a female's life. It occurs across several phases, including prenatal development, puberty, and pregnancy. At menopause, breast development ceases and the breasts atrophy.
By the widely used Tanner staging of puberty, this is stage 2 of breast development (stage 1 is a flat, prepubertal breast). Within 6–12 months, the swelling has clearly begun in both sides, softened, and can be felt and seen extending beyond the edges of the areolae. This is stage 3 of breast development.
Estrogen stimulates the development of the fibroglandular tissue, Goldman says, and therefore, any type of estrogen fluctuations inherently increase the likelihood for breast changes to happen.
(Males with KS/CHH are normally at stage I or II with genitalia, females at stage I with breast development and both males and females at stage III with pubic hair development). [3] Checking for micropenis and undescended testes (cryptorchidism) in males. Measuring testicular volume. Checking for breast development and age at menarche in females.
Short stature, delayed growth in height and weight, and/or delayed menarche may be the only clinical manifestations of celiac disease, in absence of any other symptoms. [19] [22] [23] [24] According to a review article, there may also be an association between early age at menarche and breast cancer risk. [25]
Premature thelarche is breast hypertrophy before puberty. This form of hypertrophy is an increase in breast tissue. PT occurs in pre-pubescent females, under the age of 8, having a peak occurrence in the first two years of life. [4] The breast development is usually bi-lateral: both breasts show development.