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The activated protein C resistance (APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form of hypercoagulability. [ 1 ] [ 2 ] Hereditary APC resistance is usually caused by the factor V Leiden mutation, whereas acquired APC resistance has been linked to antiphospholipid antibodies ...
The calibrated automated thrombogram (CAT or CT) is a thrombin generation assay (TGA) and global coagulation assay (GCA) which can be used as a coagulation test to assess thrombotic risk. [1] [2] It is the most widely used TGA. [3] The CAT is a semi-automated test performed in a 96-well plate and requires specialized technologists to be ...
liver function tests to exclude liver disease as a cause of coagulation factor deficiency These tests may miss mild abnormalities but they will detect major disorders. The results of these screening tests, in conjunction with the clinical history (especially bleeding history), will then direct the selection of further, more detailed and ...
Activated protein C resistance (APCR) is a hypercoagulability (an increased tendency of the blood to clot) characterized by a lack of a response to activated protein C (APC), which normally helps prevent blood from clotting excessively.
A thrombin generation assay (TGA) or thrombin generation test (TGT) is a global coagulation assay (GCA) and type of coagulation test which can be used to assess coagulation and thrombotic risk. [ 1 ] [ 2 ] [ 3 ] It is based on the potential of a plasma to generate thrombin over time, following activation of coagulation via addition of ...
Pregnancy-induced hypercoagulability is probably a physiologically adaptive mechanism to prevent post partum hemorrhage. [1] Pregnancy changes the plasma levels of many clotting factors, such as fibrinogen, which can rise up to three times its normal value. [2] Thrombin levels increase. [3] Protein S, an anticoagulant, decreases.
Coagulation activation markers are biomarkers of net activation of coagulation and fibrinolysis. [ 1 ] [ 2 ] Examples include prothrombin fragment 1+2 (F1+2), thrombin–antithrombin complex (TAT), fibrinopeptide A (FpA), fibrin monomers (FMs), plasmin-α 2 -antiplasmin complex (PAP), activated protein C–protein C inhibitor (APC-PCI), and D ...
Tests in platelet rich plasma (close to real conditions in the body, but restrictions as to the terms of work), Tests in whole blood (the most adjusted to human physiology; the test can be started immediately; but the least convenient due to terms of blood storage and difficulties of the results' interpretation).
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