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Endothelin-1 is the most powerful endogenous chemical affecting vascular tone across organ systems. [2] [13] Secretion of endothelin-1 from the vascular endothelium signals vasoconstriction and influences local cellular growth and survival. [13]
The PAT signal is a form of pulse wave amplitude measured by incorporating both a unified pressure field and a specific isosbestic wavelength.Applying a uniform pressure field around the measured surface releases arterial wall motion restriction, magnifies the dynamic range of the recorded signal, and prevents the distention of the veins distal to the site of pressure application.
The major determinant of vascular resistance is small arteriolar (known as resistance arterioles) tone. These vessels are from 450 μm down to 100 μm in diameter (as a comparison, the diameter of a capillary is about 5 to 10 μm). Another determinant of vascular resistance is the pre-capillary arterioles. These arterioles are less than 100 μm ...
Below are several examples of differing types of local blood flow regulation by specific organ type or organ system. In each case, there is a specific type of intrinsic regulation occurring in order to maintain or alter blood flow to that given organ alone, instead of creating a systemic change that would affect the entire body.
Moreover, impaired blood flow resulting from abnormal vasoconstriction may contribute to tissue ischemia, which can be observed in conditions like Raynaud's disease. Understanding the pathology of vasoconstriction is crucial for developing targeted therapeutic strategies to manage conditions associated with abnormal vascular tone. [17]
This reduces sympathetic tone to vascular smooth muscle. [9] This reduces heart rate and vascular resistance. [9] Digoxin increases vagal tone from the vasomotor centre, which decreases pulse. [7] G-series nerve agents have their most potent effect in the vasomotor center. [10]
18127 Ensembl ENSG00000164867 ENSMUSG00000028978 UniProt P29474 P70313 RefSeq (mRNA) NM_000603 NM_001160109 NM_001160110 NM_001160111 NM_008713 RefSeq (protein) NP_000594 NP_001153581 NP_001153582 NP_001153583 NP_032739 Location (UCSC) Chr 7: 150.99 – 151.01 Mb Chr 5: 24.57 – 24.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Endothelial NOS (eNOS), also known as nitric oxide ...
Arterioles contract and relax, varying their diameter and vascular tone, as the vascular smooth muscle responds to diverse stimuli. Distension of the vessels due to increased blood pressure is a fundamental stimulus for muscle contraction in arteriolar walls.