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At higher doses, niacin has been used to treat high cholesterol and triglyceride levels, since it can help lower LDL (“bad”) cholesterol and raise levels of HDL (“good”) cholesterol.
Pharmacologic (1- to 3-gram/day) niacin doses increase HDL levels by 10–30%, [61] making it the most powerful agent to increase HDL-cholesterol. [ 62 ] [ 63 ] A randomized clinical trial demonstrated that treatment with niacin can significantly reduce atherosclerosis progression and cardiovascular events. [ 64 ]
Laropiprant is a prostaglandin D2 binding drug shown to reduce niacin-induced vasodilation and flushing side effects. [47] [93] [94] A clinical trial showed no additional efficacy of Tredaptive in lowering cholesterol when used together with other statin drugs, but did show an increase in other side effects. [95]
For example, Hensrud advised against using niacin, which lowers cholesterol but has side effects, among them flushing. It also can raise liver enzymes when taken in large doses, Hensrud said ...
Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut, so they are most effective when consumed with meals. However, their precise mechanism of action differs from ezetimibe. Omega-3 supplements taken at high doses can reduce levels of triglycerides. [6] They are associated with a very modest increase in LDL (~5% ...
Dyslipidemia. Dyslipidemia is when the lipids in your blood are too high or too low. Estimates suggest that 53 percent of adults in the U.S. have lipid abnormalities.. Lipids are a type of fat ...
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