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Primary lymphedema is a form of lymphedema which is not directly attributable to another medical condition. It can be divided into three forms, depending upon age of onset: congenital lymphedema, lymphedema praecox, and lymphedema tarda. [1] Congenital lymphedema presents at birth. Lymphedema praecox presents from ages 1 to 35.
Several research groups have hypothesized that chronic inflammation is a key regulator in the development of lymphedema. Th cells, particularly Th2 differentiation, play a crucial role in the pathophysiology of lymphedema. Research has shown that increased expression of Th2-inducing cytokines in the epidermal cells of the lymphoedematous limb.
Milroy's disease is also known as primary or hereditary lymphedema type 1A or early onset lymphedema. It is a very rare disease with only about 200 cases reported in the medical literature. Milroy's disease is an autosomal dominant condition caused by a mutation in the FLT4 gene which encodes the vascular endothelial growth factor receptor 3 ...
Waldemar Lech Olszewski was born on 3 September 1931 in Piastów, Warsaw, Poland into a family of landowners, his father was a linguist and a banking specialist. He received his General Certificate of Education in 1948 in Warsaw and undertook university studies, first in the Faculty of Law, Warsaw University from 1948 to 1950 and then in the Faculty of Medicine at Warsaw University.
Neil "George" Piller is an Australian professor of lymphology at the Department of Surgery, School of Medicine, Flinders University. Piller is also the Director of the Lymphoedema Assessment Unit, Flinders Surgical Oncology as well as member of the Flinders University microcirculatory and lymphological research group. [1]
Hennekam syndrome, also known as intestinal lymphagiectasia–lymphedema–mental retardation syndrome, [1] is an autosomal recessive disorder consisting of intestinal lymphangiectasia, facial anomalies, peripheral lymphedema, and mild to moderate levels of growth and intellectual disability.
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Studies show mixed results regarding the efficacy of the method in treating lymphedema, and further studies are needed. [3] A 2013 systematic review of manual lymphatic drainage with regard to breast cancer –related lymphedema found no clear support for the effectiveness of the intervention in either preventing limb edema in at-risk women or ...
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