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A foreign body reaction (FBR) is a typical tissue response to a foreign body within biological tissue. [1] It usually includes the formation of a foreign body granuloma. [2] Tissue encapsulation of an implant is an example, as is inflammation around a splinter. [3]
A foreign-body granuloma occurs when a foreign body (such as a wood splinter, piece of metal, glass etc.) penetrates the body's soft tissue followed by acute inflammation and formation of a granuloma. [18] In some cases the foreign body can be found and removed even years after the precipitating event. [19]
The inflammatory process that creates these cells often leads to a foreign body granuloma. The human body goes through several steps when exposed to foreign biomaterial including acute and chronic inflammation , and formation of new tissue and a fibrous capsule along the surface of the implantation. [ 1 ]
Foreign-body giant cells form when a subject is exposed to a foreign substance. Exogenous substances can include talc or sutures. As with other types of giant cells, epithelioid macrophages fusing together causes these giant cells to form and grow. [13]
Gossypiboma describes a mass within a patient's body comprising a cotton matrix surrounded by a foreign body granuloma. [2] [3] Textiloma is derived from textile (surgical sponges have historically been made of cloth), and is used in place of gossypiboma due to the increasing use of synthetic materials in place of cotton. [2]
Granuloma formation and multinucleated giant cells The main purpose of cytological examination in granulomatous dermatitis is to detect infectious agents. Foreign body materials are very specific for foreign body granuloma. Granuloma annulare: Palisading granuloma and mucin Necrobiosis lipoidica: Palisading granuloma and necrobiotic materials
Silicone granulomas are a skin condition that occur as a reaction to liquid silicones, and are characterized by the formation of nodules. [1]: 46 Formation of a granuloma is a common tissue response to a range of foreign bodies.
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