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Arsenic trioxide is indicated in combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia whose acute promyelocytic leukemia is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression; and for induction of remission and consolidation in patients with acute promyelocytic leukemia who are refractory to, or ...
In the 18th century, William Withering discovered that arsenic trioxide, when used in small doses, exhibited therapeutic effects. [6] During the same period, Thomas Fowler prepared a 1% solution of arsenic and potassium carbonate, which was used to treat skin diseases (primarily psoriasis) until the 20th century. [7]
Treosulfan was approved for use in the European Union in June 2019. [8]Two main studies showed that treosulfan is at least as effective as busulfan, another medicine used to prepare patients for haematopoietic stem cell transplantation.
Melarsoprol is a prodrug, a complex of melarsen oxide (a melamine derivative of phenylarsonous acid) with dimercaprol (also known as British anti-Lewisite, or BAL). It is metabolized to melarsen oxide in the body, which then acts by irreversibly binding to sulfhydryl groups on the enzyme pyruvate kinase, thus disrupting energy production in the parasite.
It oxidises readily in air to form arsenic trioxide and water, and analogous reactions take place with sulfur and selenium instead of oxygen. [34] Arsenic forms colorless, odorless, crystalline oxides As 2 O 3 ("white arsenic") and As 2 O 5 which are hygroscopic and readily soluble in water to form acidic solutions.
Arsenic trioxide powder.. Compounds of arsenic resemble in some respects those of phosphorus which occupies the same group (column) of the periodic table.The most common oxidation states for arsenic are: −3 in the arsenides, which are alloy-like intermetallic compounds, +3 in the arsenites, and +5 in the arsenates and most organoarsenic compounds.
Obecabtagene autoleucel, sold under the brand name Aucatzyl, is an anti-cancer medication used for the treatment of acute lymphoblastic leukemia. [1] [2] It is a CD19-directed genetically modified autologous T-cell immunotherapy.
Reactions attributed to aqueous arsenic trioxide are due to arsenous acid and its conjugate bases. Like arsenic trioxide, arsenous acid is sometimes amphoteric. For example, it reacts with hydrochloric, hydrobromic, and hydroiodic acids to produce arsenic trichloride, tribromide, and triiodide. As(OH) 3 + 3 HCl ⇌ AsCl 3 + 3 H 2 O