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Arsenic trioxide binds to the cysteine at position 179 of IKKβ, thus preventing the release of NF-κB. [35] The absence of this protein in the cytoplasm allows for the induction of apoptosis via the extrinsic pathway and activates caspases 3 and 8.
Arsenic trioxide is indicated in combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia whose acute promyelocytic leukemia is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression; and for induction of remission and consolidation in patients with acute promyelocytic leukemia who are refractory to, or ...
Arsenic trioxide powder.. Compounds of arsenic resemble in some respects those of phosphorus which occupies the same group (column) of the periodic table.The most common oxidation states for arsenic are: −3 in the arsenides, which are alloy-like intermetallic compounds, +3 in the arsenites, and +5 in the arsenates and most organoarsenic compounds.
Dinitrogen trioxide – N 2 O 3; Nitric acid – HNO 3; Nitrous acid – HNO 2; Nitrogen dioxide – NO 2; Nitrogen monoxide – NO; Nitrous oxide (dinitrogen monoxide, laughing gas, NOS) – N 2 O; Nitrogen pentafluoride – NF 5; Nitrogen triiodide – NI 3
Arsenic oxide may refer to any of the following: Arsenic dioxide, As 2 O 4; Arsenic trioxide, As 2 O 3; Arsenic pentoxide, As 2 O 5
Arsenic trioxide—also known as white arsenic—is an industrially produced inorganic compound with the formula As 2 O 3. It is white or colourless and is commonly found in either powdered or crystal form—the latter resembling sugar or sand. It is used as a wood preservative and a pesticide.
The first breakthrough in the detection of arsenic poisoning was in 1775 when Carl Wilhelm Scheele discovered a way to change arsenic trioxide to garlic-smelling arsine gas (AsH 3), by treating it with nitric acid (HNO 3) and combining it with zinc. [3] As 2 O 3 + 6 Zn + 12 HNO 3 → 2 AsH 3 + 6 Zn(NO 3) 2 + 3 H 2 O
In chemistry, an arsenite is a chemical compound containing an arsenic oxyanion where arsenic has oxidation state +3. Note that in fields that commonly deal with groundwater chemistry, arsenite is used generically to identify soluble As III anions. IUPAC have recommended that arsenite compounds are to be named as arsenate(III), for example ...