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Arsenic trioxide is indicated in combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia whose acute promyelocytic leukemia is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression; and for induction of remission and consolidation in patients with acute promyelocytic leukemia who are refractory to, or ...
ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, ... L01XX27 Arsenic trioxide L01XX29 ...
Medical use of arsenic trioxide refers to the use of arsenic trioxide (Latin: Arsenum trioxydatum, [1] also known as "arsenic") as an chemotherapeutic agent in the treatment of acute promyelocytic leukemia. Arsenic trioxide has orphan drug status [2] and is available as the pharmaceutical preparation Trisenox.
Arsenic trioxide powder.. Compounds of arsenic resemble in some respects those of phosphorus which occupies the same group (column) of the periodic table.The most common oxidation states for arsenic are: −3 in the arsenides, which are alloy-like intermetallic compounds, +3 in the arsenites, and +5 in the arsenates and most organoarsenic compounds.
Arsenic trioxide [Note 2] IV: Not fully understood. Induces partial differentiation and promotes apoptosis of leukaemic cells and may also inhibit angiogenesis. Refractory or relapsed acute promyelocytic leukaemia.
Arsenic oxide may refer to any of the following: Arsenic dioxide, As 2 O 4; Arsenic trioxide, As 2 O 3; Arsenic pentoxide, As 2 O 5
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Arsenic trioxide (As 2 O 3) is currently being evaluated for treatment of relapsed/refractory disease. Remission with arsenic trioxide has been reported. [23] Studies have shown arsenic reorganizes nuclear bodies and degrades the mutant PML-RAR fusion protein. [23] Arsenic also increases caspase activity which then induces apoptosis. [23]