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Several approved drugs are being investigated as repurposed agents in the treatment of osteoarthritis such as liraglutide (anti-diabetic and anti-obesity drug: NCT02905864), Metformin (anti-diabetic drug: NCT04767841, NCT05034029), Zoledronic acid (anti-osteoporotic drug: NCT04303026), etc. [4] Paroxetine has been deemed to have dmoad activity ...
Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population, as of 2015. [4] [12] It becomes more common as people age. [1] Among those over 60 years old, about 10% of males and 18% of females are affected. [2] Osteoarthritis is the cause of about 2% of years lived with disability. [12]
Gene therapy for osteoarthritis is the application of gene therapy to treat osteoarthritis (OA). Unlike pharmacological treatments which are administered locally or systemically as a series of interventions, gene therapy aims to establish sustained therapeutic effect after a single, local injection.
Long-term results have been observed in human knee [6] and finger osteoarthritis. [7] In addition to Yttrium-90 (Y-90) and Rhenium-186 (Re-186), another radioisotope used in radiosynoviorthesis is Tin-117m (Sn-117m). Tin-117m is radioisotope that is used to treat synovitis and osteoarthritis in canines with elbow dysplasia. [8] [9] [10] [11]
This includes other types of inflammatory arthritis like RA, psoriatic arthritis, and septic arthritis. Gout can also appear similar to another condition called calcium pyrophosphate deposition ...
The OARSI (OsteoArthritis Research Society International) recommended chondroitin sulfate as the second-most-effective treatment for moderate cases of osteoarthritis (although the guidelines were published in 2008, the developers closed their search date in January 2006 – prior to the GAIT trial). [50]
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