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Summation, which includes both spatial summation and temporal summation, is the process that determines whether or not an action potential will be generated by the combined effects of excitatory and inhibitory signals, both from multiple simultaneous inputs (spatial summation), and from repeated inputs (temporal summation).
Temporal summation: When a single synapse inputs that are close together in time, their potentials are also added together. Thus, if a neuron receives an excitatory postsynaptic potential, and then the presynaptic neuron fires again, creating another EPSP, then the membrane of the postsynaptic cell is depolarized by the total sum of all the ...
A tetanic contraction (also called tetanized state, tetanus, or physiologic tetanus, the latter to differentiate from the disease called tetanus) is a sustained muscle contraction [2] evoked when the motor nerve that innervates a skeletal muscle emits action potentials at a very high rate.
The two ways that synaptic potentials can add up to potentially form an action potential are spatial summation and temporal summation. [5] Spatial summation refers to several excitatory stimuli from different synapses converging on the same postsynaptic neuron at the same time to reach the threshold needed to reach an action potential.
The summation of these three EPSPs generates an action potential. In neuroscience , an excitatory postsynaptic potential ( EPSP ) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential .
Spatial summation occurs when postsynaptic potentials from adjacent synapses on the cell occur simultaneously and add together. An action potential occurs when the summated EPSPs, minus the summated IPSPs, in an area of membrane reach the cell's threshold potential.
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Hilton's law, espoused by John Hilton in a series of medical lectures given in 1860–1862, [1] is the observation that in the study of anatomy, the nerve supplying the muscles extending directly across and acting at a given joint not only supplies the muscle, but also innervates the joint and the skin overlying the muscle.
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