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D-dimer (or D dimer) is a dimer that is a fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two D fragments of the fibrin protein joined by a cross-link , hence forming a protein dimer .
Blood clots are dangerous, so you don’t want to ignore an elevated D dimer level. Skip to main content. Sign in. Mail. 24/7 Help. For premium support please call: 800-290-4726 ...
References range may vary with age, sex, race, pregnancy, [10] diet, use of prescribed or herbal drugs and stress. Reference ranges often depend on the analytical method used, for reasons such as inaccuracy , lack of standardisation , lack of certified reference material and differing antibody reactivity . [ 11 ]
Those who finish warfarin treatment after idiopathic VTE with an elevated D-dimer level show an increased risk of recurrent VTE (about 9% vs about 4% for normal results), and this result might be used in clinical decision making. [133] Thrombophilia test results rarely play a role in the length of treatment. [80]
In people with a low or moderate suspicion of PE, a normal D-dimer level (shown in a blood test) is enough to exclude the possibility of thrombotic PE, with a three-month risk of thromboembolic events being 0.14%. [51] D-dimer is highly sensitive but not specific (specificity around 50%).
Some reference states that pregnancy can increase coagullation factors such as d-dimer and fibrin. borgx (talk) 01:08, 26 May 2006 (UTC) In pregnancy, D-dimer is likely to be elevated and loses its use a diagnostic tool. No different normal range is used, because by increasing the cutoff you'd lose its sensitivity.
Pregnancy-induced hypercoagulability is probably a physiologically adaptive mechanism to prevent post partum hemorrhage. [1] Pregnancy changes the plasma levels of many clotting factors, such as fibrinogen, which can rise up to three times its normal value. [2] Thrombin levels increase. [3] Protein S, an anticoagulant, decreases.
Pregnancy is associated with an increased risk of thrombosis of 2- to 7-fold. [25] This probably results from a physiological hypercoagulability in pregnancy that protects against postpartum hemorrhage. [26] This hypercoagulability in turn is likely related to the high levels of estradiol and progesterone that occur during pregnancy. [27]