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Childhood-onset systemic lupus erythematosus (i.e., cSLE), also termed juvenile-onset systemic lupus erythematosus, juvenile systemic lupus erythematosus, and pediatric systemic lupus erythematosus, is a form of the chronic inflammatory and autoimmune disease, systemic lupus erythematosus (i.e., SLE), that develops in individuals up to 18 years old. [1]
The majority of cases involve the central nervous system (CNS), which consists of the brain and spinal cord. [2] The most common CNS syndromes are headache and mood disorder. [1] Though neuropsychiatric lupus is sometimes referred to as "CNS lupus", it can also affect the peripheral nervous system (PNS).
Men have higher mortality. [8] SLE significantly increases the risk of cardiovascular disease, with this being the most common cause of death. [5] While women with lupus have higher risk pregnancies, most are successful. [1] Rate of SLE varies between countries from 20 to 70 per 100,000. [2]
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The overall life expectancy of Americans fell by 2.7 years from 2019 to 2021, and COVID-19 is not fully to blame, researchers say. Life expectancy for men now 6 years shorter than for women Skip ...
The "healthspan-lifespan gap" was largest in the U.S., as Americans live in poor health for an average of 12.4 years, compared to 10.9 years in 2000.
The idea behind the "mixed" disease is that this specific autoantibody is also present in other autoimmune diseases such as systemic lupus erythematosus, polymyositis, scleroderma, etc. MCTD was characterized as an individual disease in 1972 by Sharp et al., [3] [4] and the term was introduced by Leroy [5] in 1980. [6]
Women are far more likely than men to get autoimmune diseases, when an out-of-whack immune system attacks their own bodies — and new research may finally explain why. ... More than 24 million ...
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