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Status epilepticus (SE), or status seizure, is a medical condition with abnormally prolonged seizures.It can have long-term consequences, [3] manifesting as a single seizure lasting more than a defined time (time point 1), or 2 or more seizures over the same period without the person returning to normal between them.
Status epilepticus: Although rare, focal motor status or hemiconvulsive status epilepticus is more likely to occur than secondarily generalized convulsive status epilepticus, which is exceptional. [ 12 ] [ 13 ] Opercular status epilepticus usually occurs in children with atypical evolution or may be induced by carbamazepine or lamotrigine.
Convulsive status epilepticus that does not respond to initial treatment typically requires admission to the intensive care unit and treatment with stronger agents such as midazolam infusion, ketamine, thiopentone or propofol. [106] Most institutions have a preferred pathway or protocol to be used in a seizure emergency like status epilepticus ...
[3] [8] If a seizure lasts longer than 5 minutes, it is a medical emergency (status epilepticus) and needs immediate treatment. [3] [5] [9] Seizures can be classified as provoked or unprovoked. [3] [6] Provoked seizures have a cause that can be fixed, such as low blood sugar, alcohol withdrawal, high fever, recent stroke, and recent head trauma.
[2] [5] It is a type of new-onset refractory status epilepticus (NORSE). [5] The seizures are often resistant to treatment. [2] High doses of benzodiazepines or barbiturates are often used, with care taking place in the intensive care unit. [2] A ketogenic diet may help in some cases. [1] The medications anakinra or tocilizumab have been tried. [2]
Febrile status epilepticus is a subtype of complex febrile seizures that lasts for longer than 30 minutes. [7] It can occur in up to 5% of febrile seizure cases. [ 13 ]
Marinus Pharmaceuticals Inc (NASDAQ: MRNS) expects data from the RAISE Phase 3 trial of ganaxolone in refractory status epilepticus in 2H of 2023. Earlier data from the trial was expected in 2H of ...
Status epilepticus with myoclonic, astatic, myoclonic-astatic, or absence seizures is another ominous sign, especially when prolonged or appearing early. Failure to suppress the EEG abnormalities (4- to 7-Hz rhythms and spike-wave discharges) during therapy and absence of occipital alpha-rhythm with therapy also suggest a poor prognosis (Doose ...