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Sound above a certain decibel level can cause permanent damage to inner ear stereocilia. New research has shown that the damage can possibly be reversed if we can repair or recreate some of the proteins in the stereocilia. In this study, scientists used zebrafish to examine the motion of proteins within live ear cells using a confocal ...
They are distinct from cilia and microvilli, but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal cell membrane characteristics. They contain actin. Stereocilia are found in the vas deferens, the epididymis, and the sensory cells of the inner ear.
Some motile cilia lack the central pair, and some non-motile cilia have the central pair, hence the four types. [5] [7] Most non-motile cilia, termed primary cilia or sensory cilia, serve solely as sensory organelles. [8] [9] Most vertebrate cell types possess a single non-motile primary cilium, which functions as a cellular antenna.
The inner ear (internal ear, auris interna) is the innermost part of the vertebrate ear. In vertebrates , the inner ear is mainly responsible for sound detection and balance. [ 1 ] In mammals , it consists of the bony labyrinth , a hollow cavity in the temporal bone of the skull with a system of passages comprising two main functional parts: [ 2 ]
A kinocilium is a special type of cilium on the apex of hair cells located in the sensory epithelium of the vertebrate inner ear. Contrasting with stereocilia, which are numerous, there is only one kinocilium on each hair cell. The kinocilium can be identified by its apical position as well as its enlarged tip. [1]
The semicircular canals are three semicircular interconnected tubes located in the innermost part of each ear, the inner ear. The three canals are the lateral, anterior and posterior semicircular canals. They are the part of the bony labyrinth, a periosteum-lined cavity on the petrous part of the temporal bone filled with perilymph.
Tip links are extracellular filaments that connect stereocilia to each other or to the kinocilium in the hair cells of the inner ear. [ 1 ] [ 2 ] Mechanotransduction is thought to occur at the site of the tip links, which connect to spring-gated ion channels. [ 3 ]
The height of hair bundles increases from base to apex and the number of stereocilia decreases (i.e. hair cells located at the base of the cochlea contain more stereo cilia than those located at the apex). [14] Furthermore, in the tip-link complex of cochlear hair cells, tonotopy is associated with gradients of intrinsic mechanical properties. [15]