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Extracts from Camptotheca (the "happy tree" or "cancer tree") were used to develop the chemotherapeutic drug Topotecan. Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or prevention of cancer in humans. [1] [2]
Cancer related to one's occupation is believed to represent between 2–20% of all cases. [17] Most cancer deaths caused by occupational risk factors occur in the developed world. [16] Job stress does not appear to be a significant factor at least in lung, colorectal, breast and prostate cancers. [18]
However, once cancer begins, cancer cells undergo a process of natural selection: the few cells with new genetic changes that enhance their survival or reproduction multiply faster, and soon come to dominate the growing tumor as cells with less favorable genetic change are out-competed. [68]
Although a DNA repair deficiency can predispose a cell lineage to develop cancer, increased (rather than decreased) expression of a repair capability may also emerge in the progression of cancer cell lineages, and this capability may be clinically important as reviewed by Lingg et al. [9] For instance, the DNA repair gene DMC1 encodes a protein ...
Those cancers that may develop as a result of radiation exposure are indistinguishable from those that occur naturally or as a result of exposure to other carcinogens. Furthermore, National Cancer Institute literature indicates that chemical and physical hazards and lifestyle factors, such as smoking, alcohol consumption, and diet ...
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Cancer is a very ancient pathology that emerged with multicellular organisms. Hosts, therefore, have had billions of years to co-evolve with cancers. Over evolutionary time hosts develop an increasing number of cancer suppressors (e.g. cytotoxic lymphocytes, Natural Killer cells, suppressor gene such as p53 copy number of those genes. [3]
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