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Hypoprothrombinemia can be the result of a genetic defect, may be acquired as the result of another disease process, or may be an adverse effect of medication.For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant ...
Protein C is vitamin K-dependent. Patients with Protein C deficiency are at an increased risk of developing skin necrosis while on warfarin. Protein C has a short half life (8 hour) compared with other vitamin K-dependent factors and therefore is rapidly depleted with warfarin initiation, resulting in a transient hypercoagulable state.
Colucci, Mario; Binetti, Bianca M.; Tripodi, Armando; Chantarangkul, Veena; Semeraro, Nicola (March 15, 2004). "Hyperprothrombinemia associated with prothrombin ...
The chemical structure of cefotetan, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain.As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse ...
Hypoprothrombinemia - if contains methylthiotetrazole side group; Allergic reactions; Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Cefoxitin: Cefotetan: Cefotan: Cefamandole: Cefmetazole: Cefonicid: Loracarbef: Cefprozil: Cefzil: Cefuroxime: Ceftin, Zinacef (UK)
Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic.The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.
Kappadione is a vitamin K derivative used for the treatment of side effects of vitamin K antagonists such as warfarin, prophylaxis and treatment of vitamin K deficiency bleeding, and hypoprothrombinemia due to various causes. [1] It was manufactured by Eli Lilly and Company. [2] Chemically, it is menadiol sodium diphosphate.
Factor X deficiency (X as Roman numeral ten) is a bleeding disorder characterized by a lack in the production of factor X (FX), an enzyme protein that causes blood to clot in the coagulation cascade.