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Thereafter, the otic cup closes off, creating the otic vesicle. Once formed, the otic vesicle will reside next to the neural tube medially, and on the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across ...
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Around the 28th day, parts of the otic vesicle begin to form the vestibulocochlear nerve. [20] [22] These form bipolar neurons, which supply sensation to parts of the inner ear (namely the sensory parts of the semicircular canals, macular of the utricle and saccule, and organ of Corti). [20] Around the 33rd day, the vesicles begin to differentiate.
The cochlear duct develops from the ventral otic vesicle (otocyst). [3] It grows slightly flattened between the middle and outside of the body. [3] This development may be regulated by the genes EYA1, SIX1, GATA3, and TBX1. [3] The organ of Corti develops inside the cochlear duct. [4]
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During the stage of neural plate formation the embryo consists of three cell layers: the ectoderm that eventually forms the skin and neural tissues, the mesoderm that forms muscle and bone, and the endoderm that will form the cells lining the digestive and respiratory tracts.
The ear, including both the vestibular system and the auditory system, develops from the otic placode beginning the third week of development. During the fourth week, the otic placode invaginates into the mesenchyme adjacent to the rhombencephalon to form the otic pit, which then pinches off from the surface ectoderm to form the otic vesicle. [1]
The optic vesicle will then induce the ectoderm that thickens (lens placode) and further invaginates to a point that detaches from the ectoderm and forms a neurogenic placode by itself. The lens placode is affected by the chordamesoderm making it invaginate and forms the optic cup composed by an inner layer of the neural retina and outer layer ...