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It is a Janus kinase inhibitor selective for JAK1 and JAK2. [2] Although the relative effectiveness of deuruxolitinib and another Janus kinase inhibitor—baricitinib—for alopecia areata may vary depending on the population studied, both drugs are more effective than alternative treatments. [3]
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, [1] is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.
Ritlecitinib is a kinase inhibitor which inhibits Janus kinase 3 and tyrosine kinase. [6] [9] [10] The most common side effects include headache, diarrhea, acne, rashes, eczema, fever, mouth ulcers, dizziness, shingles rash, and abnormal findings in some laboratory test results. [11]
Using ones own cells and tissues and without harsh side effects, PRP is beneficial for alopecia areata [48] and androgenetic alopecia and can be used as an alternative to minoxidil or finasteride. [49] It has been documented to improve hair density and thickness in both genders. [50]
Ivarmacitinib (SHR0302) is a small molecule drug and selective janus kinase 1 (JAK1) inhibitor. It is being developed for ulcerative colitis , [ 1 ] eczema , alopecia areata , and graft-versus-host disease .
Baricitinib is a Janus kinase (JAK) inhibitor that reversibly inhibits Janus kinase 1 with a half maximal inhibitory concentration (IC 50) of 5.9 nM and Janus kinase 2 with an IC 50 of 5.7 nM. Tyrosine kinase 2 , which belongs to the same enzyme family, is affected less (IC 50 = 53 nM), and Janus kinase 3 far less (IC 50 > 400 nM).
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