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2. Sildenafil - Wikipedia

   en.wikipedia.org/wiki/Sildenafil

   Sildenafil acts by blocking phosphodiesterase 5 (PDE 5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. [8]

3. Is Sildenafil Safe for This Common Male Problem? - AOL

   www.aol.com/sildenafil-safe-common-male-problem...

   Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.

4. Your ED Pill Guide: Everything You Need to Know Before ... - AOL

   www.aol.com/ed-pill-guide-everything-know...

   Viagra (or sildenafil) lasts three to five hours after it’s consumed. Cialis (tadalafil) has a half-life of 17.5 hours, meaning this drug lasts up to 36 hours after it’s consumed.

5. How Much Viagra Is Too Much? - AOL

   www.aol.com/much-viagra-too-much-105700581.html

   Sildenafil is the active ingredient in the medication and the name for generic Viagra. Viagra and Revatio are the drug’s brand names. Viagra doses range from 25 to 100 milligrams (mg). A typical ...

6. PDE5 inhibitor - Wikipedia

   en.wikipedia.org/wiki/PDE5_inhibitor

   Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

7. What Does Viagra Actually Do to Your "Intimate" Experience? - AOL

   www.aol.com/does-viagra-actually-intimate...

   Sildenafil — does this by inhibiting an enzyme referred to as phosphodiesterase type 5, or PDE5. The PDE5 enzyme helps control blood flow to your privates. PDE5 normally breaks down cGMP, which ...

8. Discovery and development of phosphodiesterase 5 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   Sildenafil is a prototype of PDE5 inhibitors that Pfizer launched as Viagra. It was approved by the Food and Drug Administration (FDA) in 1998 as the first oral medicine for erectile dysfunction. Later, in the year 2005, it was approved for the treatment of pulmonary arterial hypertension. [ 2 ]

9. Does Viagra Help Me Last Longer in Bed? - AOL

   www.aol.com/does-viagra-help-last-longer...

   Viagra (sildenafil citrate) is a type of ED \ medication called a phosphodiesterase type 5 inhibitor. PDE5 inhibitors such as Viagra, Cialis and Levitra (vardenafil) are designed to treat ED by ...