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Hemoglobin electrophoresis is a blood test that can detect different types of hemoglobin. The test can detect hemoglobin S, the form associated with sickle cell disease, as well as other abnormal types of hemoglobin, such as hemoglobin C. It can also be used to investigate thalassemias, which are disorders caused by defective hemoglobin production.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders that are typically inherited. [2] The most common type is known as sickle cell anemia. [2] Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]
Testing HbA2 levels can be challenging because different disorders can cause it to have higher or lower values. Testing for the beta-thalassemia trait is usually identified when the value of HbA2 is higher than 3.5%. [3] HbA2 is also important for diagnosing sickle cell disease, which is one of the most prevalent genetic conditions.
The sickle cell trait provides a survival advantage against malaria fatality over people with normal hemoglobin in regions where malaria is endemic. The trait is known to cause significantly fewer deaths due to malaria, especially when Plasmodium falciparum is the causative organism.
The mean corpuscular hemoglobin concentration (MCHC) is a measure of the concentration of hemoglobin in a given volume of packed red blood cell. It is calculated by dividing the hemoglobin by the hematocrit. Reference ranges for blood tests are 32 to 36 g/dL (320 to 360g/L), [1] or between 4.81 and 5.58 mmol/L. It is thus a mass or molar ...
The increase in the surface area to volume ratio also gives the cell decreased osmotic fragility, as it allows it to take up more water for a given amount of osmotic stress. In vivo (within the blood vessel), the codocyte is a bell-shaped cell. It assumes a "target" configuration only when processed to obtain a blood film.
CHICAGO (Reuters) -Quest Diagnostics on Monday launched the first direct-to-consumer blood test to detect abnormal levels of beta amyloid, a key Alzheimer's disease protein that can appear years ...
Gaston was told to run a blood test to check for sickle cell disease, and sure enough, the baby was suffering from a sickle cell infection. The thought of running a blood test for sickle cell disease had never occurred to her, so she became committed to learning all she could about this disease by working with the National Institutes for Health ...