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Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [ 19 ]
Effects on heart related health problems or death is unclear. [3] Common side effects include tingling, dizziness, trouble sleeping, and constipation. [3] Serious side effects may include suicide, abuse. [3] Use is not recommended during pregnancy. [1] Phentermine is a stimulant and appetite suppressant. [3]
The FDA requested that the manufacturers of fenfluramine and dexfenfluramine stress the potential risk to the heart in the drugs' labeling and in package inserts. [11] The FDA continued to receive reports in 1997 of valvular heart disease in people who had taken these drugs. This disease typically involves the aortic and mitral valves.
In the United States, the 800 mcg tablet was 6.75 times more expensive as of 2020 than the lozenge. [ 208 ] [ 209 ] As of 2023, the average cost for an injectable fentanyl solution (50 mcg/mL) is around US $17 for a supply of 20 milliliters, depending on the pharmacy. [ 210 ]
Adderall and Mydayis [11] are trade names [note 2] for a combination drug containing four salts of amphetamine.The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. [13]
Tramadol, sold under the brand name Ultram among others, [1] is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderately severe pain.
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. [6] [9] It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. [9]
The 7.5 cm Infanteriegeschütz 37 (7.5 cm IG 37) was an infantry support gun, used by Germany during World War II.The guns were originally designated 7.5 cm PaK 37.The IG 37s were manufactured from carriages of 3.7 cm Pak 36s (and the nearly identical Soviet 3.7 cm PaK 158(r)) and a barrel designed originally for the IG 42 infantry support gun.
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