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The ductus venosus naturally closes during the first week of life in most full-term neonates; however, it may take much longer to close in pre-term neonates. Functional closure occurs within minutes of birth. Structural closure in term babies occurs within 3 to 7 days. After the ductus venosus closes, its remnant is known as ligamentum venosum.
First, the ductus venosus was previously kept open by the blood flow from the umbilical vein. The reduced blood flow through the umbilical vein at birth will collapse and close the ductus venosus. Hence, the IVC will only carry deoxygenated blood from the infant's organs and lower extremities.
The ductus venosus joins the terminal portion of the IVC, just before the right atrium. Before the ductus venosus joins the IVC, it is positioned in such a way that the oxygenated blood flowing into the IVC from the ductus venosus preferentially passes on the side of the crista dividens that directs the blood stream toward the left atrium.
The unpaired umbilical vein carries oxygen and nutrient rich blood derived from fetal-maternal blood exchange at the chorionic villi.More than two-thirds of fetal hepatic circulation is via the main portal vein, while the remainder is shunted from the left portal vein via the ductus venosus to the inferior vena cava, eventually being delivered to the fetal right atrium.
The ligamentum venosum, also known as Arantius' ligament, [1] is the fibrous remnant of the ductus venosus of the fetal circulation. Usually, it is attached to the left branch of the portal vein within the porta hepatis. It may be continuous with the round ligament of liver.
The ductus arteriosus, also called the ductus Botalli, named after the Italian physiologist Leonardo Botallo, is a blood vessel in the developing fetus connecting the trunk of the pulmonary artery to the proximal descending aorta. It allows most of the blood from the right ventricle to bypass the fetus's fluid-filled non-functioning lungs.
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The severity of symptoms depends on the type of TGV, and the type and size of other heart defects that may be present (ventricular septal defect, atrial septal defect, or patent ductus arteriosus). Most babies with TGA have blue skin color (cyanosis) in the first hours or days of their lives, since dextro-TGA is the more common type.