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"rare and mild gastrointestinal upset, headaches, diarrhea, gynecomastia, paroxysmal atrial fibrillation, ventricular rupture and death in one patient" [3] Senna: Egyptian senna Senna alexandrina (Cassia senna) "abdominal pain, diarrhea, potentially carcinogenic, with others can potentiate cardiac glycosides and antiarrhythmic agents", [3 ...
[citation needed] Symptoms in children can include lethargy, sedation and seizure. [18] Synthetic cannabis is suspected of being a potential contributory factor or direct cause of sudden death, due to the strain it can place on the cardiovascular system, or because of cannabinoid hyperemesis syndrome. [19]
The most common symptoms are vomiting and diarrhea. However, additional symptoms may occur, including chills, nausea, headache, abdominal cramps, myalgia , and fever though it is very rare. While patients frequently start to show symptoms after the 1–4 day incubation period, there have been cases in which an individual is asymptomatic.
[4] [20] CBD does not have the same psychoactivity as THC, [25] [26] and can modulate the psychoactive effects of THC on the body if both are present. [17] [25] [27] [28] Conversion of CBD to THC can occur when CBD is heated to temperatures between 250–300 °C, potentially leading to its partial transformation into THC. [29]
7-Hydroxycannabidiol (7-OH-CBD) is an active metabolite of cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. [1] While methods have been developed for its synthetic production, [2] and measurement of levels in the body following consumption of cannabidiol, [3] its pharmacology has been relatively little studied, though it has been found to possess similar ...
Abnormal cannabidiol (Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive or sedative effects.
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Weekly cannabis use is generally required for the syndrome to occur; synthetic cannabinoids can also cause CHS. [6] [5] The underlying mechanism is unclear, with several possibilities proposed. [2] [5] Diagnosis is based on the symptoms, as well as the history of cannabis use (including a urine screen test if necessary). [6]