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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
Evidence for the monoamine theory comes from multiple areas. First, acute depletion of tryptophan—a necessary precursor of serotonin and a monoamine—can cause depression in those in remission or relatives of people who are depressed, suggesting that decreased serotonergic neurotransmission is important in depression. [64]
Theories of a proposed stress–illness link suggest that both acute and chronic stress can cause illness, and studies have found such a link. [58] According to these theories, both kinds of stress can lead to changes in behavior and in physiology. Behavioral changes can involve smoking and eating habits and physical activity.
Causes: Family history, previous diagnosis of a mood disorder, trauma, stress or major life changes in the case of depression, physical illness or use of certain medications. Depression has been linked to major diseases such as cancer, diabetes, Parkinson's disease and heart disease, Brain structure and function in the case of bipolar disorder. [1]
Epigenetics of depression is the study of how epigenetics (heritable characteristics that do not involve changes in DNA sequence) contribute to depression. Major depressive disorder is heavily influenced by environmental and genetic factors.
Depression affects around 14.8 million adults in the U.S. That?s around 7 percent of the entire population aged 18 and over.
[15] [16] A family history of depression increases the chance of being diagnosed. [17] There are usually a combination of biological, psychological, and social factors that play into a person's depression. [2] [18] A major depressive episode can often follow acute stress in someone's life, such as the death of a loved one or being fired from a ...
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