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“Lung cancer continues to be the leading cause of death in both men and women in the US, with over 158,900 deaths in 1999. Worldwide, lung cancer kills over 1 million people a year. Extensive prospective epidemiologic data clearly establish cigarette smoking as the major cause of lung cancer.
One hundred years ago, lung cancer was a reportable condition and now it accounts for more deaths worldwide from cancer than any other malignant disease. In 1912, Adler published a book entitled Primary Malignant Growths of the Lungs and Bronchi, where he reported all cases of lung cancer in the published literature worldwide.
History of Lung Cancer Causation Theories. Lung cancer is a chronic disease with multiple causation theories imbedded in the history of the disease that span more than 100 years.
Lung cancer, disease characterized by uncontrolled growth of cells in the lungs. Lung cancer was first described in the mid-19th century. In the early 20th century it was considered relatively rare, but by the 21st century it had emerged as a leading cause of cancer-related death.
Lung cancer or bronchogenic carcinoma refers to tumors originating in the lung parenchyma or within the bronchi. It is one of the leading causes of cancer-related deaths in the United States. Since 1987, lung cancer has been responsible for more deaths in women than breast cancer.
As newer therapies for lung cancer are being explored it becomes more important to understand the natural history of lung cancer.
In 1912, Isaac Adler published the first literature review about lung cancer. 1 He listed the known 374 cases mentioned in several European registries over the preceding 50 years. Most physicians at the time thought of lung cancer as an extremely rare disease, and Dr. Adler suspected that lung cancer was underdiagnosed.