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Macrophage migration inhibitory factor (MIF) is a key regulatory cytokine within innate and adaptive immune responses, capable of promoting and modulating the magnitude of the response. [1] MIF is released from T-cells and macrophages, and acts within the neuroendocrine system.
After extensive discussion and debate, in April 2014, the European Parliament approved both MiFID 2, an updated version of MiFID 1, and its accompanying Regulation (EU) No 600/2014. [6] The directive and regulation include fewer exemptions and expand the scope of MiFID 1 to cover a larger group of companies and financial products.
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MIF-1 is unusually resistant to metabolism in the bloodstream, [32] and crosses the blood–brain barrier easily, [33] [34] though it is poorly active orally and is usually injected. Several other closely related peptides with important actions in the body include Tyr-MIF-1 and endomorphin -1 and -2.
The MIF protein superfamily also includes a second member with functionally related properties, the D-dopachrome tautomerase (D-DT). [8] CD74 is a surface receptor for MIF. [9] Bacterial antigens stimulate white blood cells to release MIF into the blood stream. [10] The circulating MIF binds to CD74 on other immune cells to trigger an acute ...
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Commission Delegated Regulation (EU) 2016/128 of 25 September 2015 supplementing Regulation (EU) No 609/2013 of the European Parliament and of the Council as regards the specific compositional and information requirements for food for special medical purposes (Text with EEA relevance) Image title: Author: www.legislation.gov.uk: Software used ...
Commission Delegated Regulation (EU) 2016-522 of 17 December 2015 supplementing Regulation (EU) No 596-2014 of the European Parliament and of the Council as regards an exemption for certain third countries public bodies and central banks, the indicators of market manipulation, the disclosure thresholds, the competent authority for notifications of delays, the permission for trading during ...