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However, the appearance of uncontrollable emotions is commonly associated with many additional neurological disorders such as attention deficit hyperactivity disorder, [5] Parkinson's disease, [6] cerebral palsy, [7] autism, [8] epilepsy, [9] and migraines. [10]
The most common disorders of laughter are associated with pseudobulbar palsy, which can be caused by severe brain trauma, most commonly in the right hemisphere. Pathological laughter in this can be triggered by trivial stimuli, which could be disconnected from the underlying mood, and be combined with crying.
Paradoxical laughter has been consistently identified as a recurring emotional-cognitive symptom in schizophrenia diagnosis. Closely linked to paradoxical laughter is the symptom; inappropriate affect, defined by the APA Dictionary of Psychology as "emotional responses that are not in keeping with the situation or are incompatible with expressed thoughts or wishes". [3]
The main sign of a gelastic seizure is a sudden outburst of laughter with no apparent cause. [1] The laughter may sound unpleasant and sardonic rather than joyful. The outburst usually lasts for less than a minute. During or shortly after a seizure, an individual might display some twitching, strange eye movements, lip smacking, fidgeting or ...
The dopamine D 1 receptor appears to have an important role in motivation and reward. [38] Centrally acting dopamine D 1-like receptor agonists like tavapadon and razpipadon and D 1 receptor positive modulators like mevidalen and glovadalen are under development for medical use, including treatment of Parkinson's disease and notably of dementia ...
In adolescents, emotional dysregulation is a risk factor for many mental health disorders including depressive disorders, anxiety disorders, post-traumatic stress disorder, bipolar disorder, borderline personality disorder, substance use disorder, alcohol use disorder, eating disorders, oppositional defiant disorder, and disruptive mood ...
When induced, the affected person typically engages in such behaviors as screaming, cursing, dance movements, uncontrollable laughter, mimicry and command obedience. [1] Physical symptoms include an increased heart rate and profuse sweating, but no clear physiological causality beyond the apparent relationship between sudden shock and/or severe ...
It is here that Kean brings up the cerebellum, the center in the brain that controls finer movements, controls the timing of movement. Very important. It was probable that a malfunction in this area of the brain was what was the root of kuru, as the symptoms (shuffling, uncontrollable laughing) were typical of that area of the brain.