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Anion gap can be classified as either high, normal or, in rare cases, low. Laboratory errors need to be ruled out whenever anion gap calculations lead to results that do not fit the clinical picture. Methods used to determine the concentrations of some of the ions used to calculate the anion gap may be susceptible to very specific errors.
k H CO 2 is a constant including the solubility of carbon dioxide in blood. k H CO 2 is approximately 0.03 (mmol/L)/mmHg; p CO 2 is the partial pressure of carbon dioxide in the blood; Combining these equations results in the following equation relating the pH of blood to the concentration of bicarbonate and the partial pressure of carbon ...
The anion gap (AG) without potassium is calculated first and if a metabolic acidosis is present, results in either a high anion gap metabolic acidosis (HAGMA) or a normal anion gap acidosis (NAGMA). A low anion gap is usually an oddity of measurement, rather than a clinical concern.
The bicarbonate ion (hydrogencarbonate ion) is an anion with the empirical formula HCO − 3 and a molecular mass of 61.01 daltons; it consists of one central carbon atom surrounded by three oxygen atoms in a trigonal planar arrangement, with a hydrogen atom attached to one of the oxygens.
High anion gap metabolic acidosis is a form of metabolic acidosis characterized by a high anion gap (a medical value based on the concentrations of ions in a patient's serum). Metabolic acidosis occurs when the body produces too much acid , or when the kidneys are not removing enough acid from the body.
It is an oxocarbon anion that consists solely of carbon and oxygen. It is the anion of peroxycarbonic acid [1] [2] also called hydroperoxyformic acid, [3] HO−O−CO−OH. The peroxycarbonate anion is formed, together with peroxydicarbonate C 2 O 2− 6, at the negative electrode during electrolysis of molten lithium carbonate. [4]
In more acid conditions, aqueous carbon dioxide, CO 2 (aq), is the main form, which, with water, H 2 O, is in equilibrium with carbonic acid – the equilibrium lies strongly towards carbon dioxide. Thus sodium carbonate is basic, sodium bicarbonate is weakly basic, while carbon dioxide itself is a weak acid.
Winter's Formula quantifies the amount of respiratory compensation during metabolic acidosis. [8] During metabolic acidosis, a decrease in pH stimulates chemoreceptors. Peripheral chemoreceptors are found in the aortic and carotid bodies and respond to changes in the PaCO2, the arterial partial pressure of carbon dioxide.