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Classical examples of polarized cells are described below, including epithelial cells with apical-basal polarity, neurons in which signals propagate in one direction from dendrites to axons, and migrating cells. Furthermore, cell polarity is important during many types of asymmetric cell division to set up functional asymmetries between ...
Another MAP whose function has been investigated during cell division is known as XMAP215 (the "X" stands for Xenopus). XMAP215 has generally been linked to microtubule stabilization. During mitosis the dynamic instability of microtubules has been observed to rise approximately tenfold. This is partly due to phosphorylation of XMAP215, which ...
An oocyte with poles depicted. In developmental biology, an embryo is divided into two hemispheres: the animal pole and the vegetal pole within a blastula.The animal pole consists of small cells that divide rapidly, in contrast with the vegetal pole below it.
The development of new molecular tools including GFP, and major advances in imaging technology including fluorescence microscopy, have made possible the mapping of the cell lineage of Caenorhabditis elegans including its embryo. [7] [8] This technique of fate mapping is used to study cells as they differentiate and gain specified
How epithelial cells generate and maintain polarity remains unclear, but certain molecules have been found to play a key role. A variety of molecules are located at the apical membrane , but only a few key molecules act as determinants that are required to maintain the identity of the apical membrane and, thus, epithelial polarity.
Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor , which passes the biological signal to the Dishevelled protein inside the ...
Plasma membranes exhibit electrochemical polarity through establishment and maintenance of a resting membrane potential. Cells with polarized plasma membranes must buffer and adequately distribute certain ions, such as sodium (Na + ), potassium (K + ), calcium (Ca 2+ ), and chloride (Cl - ) to establish and maintain this polarity.
There are two distinctive mapping approaches used in the field of genome mapping: genetic maps (also known as linkage maps) [7] and physical maps. [3] While both maps are a collection of genetic markers and gene loci, [8] genetic maps' distances are based on the genetic linkage information, while physical maps use actual physical distances usually measured in number of base pairs.