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  2. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...

  3. Tacrolimus - Wikipedia

    en.wikipedia.org/wiki/Tacrolimus

    Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. [ 14 ] [ 15 ] Long-term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids , mycophenolate , and IL-2 receptor inhibitors such as basiliximab .

  4. mTOR inhibitors - Wikipedia

    en.wikipedia.org/wiki/MTOR_inhibitors

    mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...

  5. Merck Announces FDA Acceptance of New Drug Application ... - AOL

    www.aol.com/news/2013-04-10-merck-announces-fda...

    Frequent monitoring of cyclosporine or tacrolimus whole blood trough concentrations should be performed during and at discontinuation of NOXAFIL treatment and the tacrolimus or cyclosporine dose ...

  6. Immunosuppressive drug - Wikipedia

    en.wikipedia.org/wiki/Immunosuppressive_drug

    Tacrolimus (trade names Prograf, Astagraf XL, Envarsus XR) is a product of the bacterium Streptomyces tsukubensis. It is a macrolide lactone and acts by inhibiting calcineurin . The drug is used primarily in liver and kidney transplantations, although in some clinics it is used in heart, lung, and heart/lung transplantations.

  7. Trump promises to make 'major pardons' for Jan. 6 rioters who ...

    www.aol.com/trump-promises-major-pardons-jan...

    Donald Trump said during a press conference that he will make “major pardons” for Jan. 6 defendants who stormed the Capitol four years ago.

  8. Texas Teen Allegedly Fatally Poisoned Classmate's Show Goat ...

    www.aol.com/texas-teen-allegedly-fatally...

    A Texas teen is accused of killing a classmate’s show goat by force-feeding it pesticide. Aubrey Vanlandingham, 17, is charged with cruelty to livestock animals, a felony, according to court ...

  9. Therapeutic drug monitoring - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_drug_monitoring

    3) Regarding dosage adjustment to recommend, this TDM result suggests that a doubled dose of 800 mg daily might be suitable to drive the concentration curve close to target (blue dotted line). Note that this interpretation assumes that the patient's adherence to prescription is good, and that the sample measurement is accurate.

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