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  2. Tyrosine hydroxylase deficiency - Wikipedia

    en.wikipedia.org/.../Tyrosine_hydroxylase_deficiency

    In order to diagnose tyrosine hydroxylase deficiency, a sample of the patient's cerebrospinal fluid may be obtained to assess neurotransmitter metabolites that may be affected, as illustrated by the metabolic links in Figure 1. Patients typically have normal levels of 5-hydroxyindolacetic acid (5HIAA), low levels of homovanillic acid (HVA) and ...

  3. Tyrosinase - Wikipedia

    en.wikipedia.org/wiki/Tyrosinase

    In humans, tyrosinase is sorted into melanosomes [13] and the catalytically active domain of the protein resides within melanosomes. Only a small, enzymatically inessential part of the protein extends into the cytoplasm of the melanocyte. As opposed to fungal tyrosinase, human tyrosinase is a membrane-bound glycoprotein and has 13% carbohydrate ...

  4. Tyrosine hydroxylase - Wikipedia

    en.wikipedia.org/wiki/Tyrosine_hydroxylase

    Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). [5] [6] It does so using molecular oxygen (O 2), as well as iron (Fe 2+) and tetrahydrobiopterin as cofactors.

  5. Dying To Be Free - The Huffington Post

    projects.huffingtonpost.com/dying-to-be-free...

    After introducing medically assisted treatment in 2013, Seppala saw Hazelden’s dropout rate for opiate addicts in the new revamped program drop dramatically. Current data, which covers between January 1, 2013 and July 1, 2014, shows a dropout rate of 7.5 percent compared with the rate of 22 percent for the opioid addicts not in the program.

  6. Tyrosine aminotransferase - Wikipedia

    en.wikipedia.org/wiki/Tyrosine_aminotransferase

    Keratitis in Tyrosinemia type II patients is caused by the deposition of tyrosine crystals in the cornea and results in corneal inflammation. [11] The TAT gene is located on human chromosome 16q22-24 and extends over 10.9 kilobases (kb) containing 12 exons, and its 3.0 kb mRNA codes for a 454-amino acid protein of 50.4 kDa. [ 12 ]

  7. Victims of Trafficking and Violence Protection Act of 2000

    en.wikipedia.org/wiki/Victims_of_Trafficking_and...

    The bill also amended the Trafficking Victims Protection Act of 2000 to direct the United States Secretary of Health and Human Services (HHS) to make a determination, based on credible evidence, that a covered individual (i.e., a U.S. citizen or a permanent resident) has been a victim of a severe form of trafficking. [5]

  8. 350 Miles Away - The Huffington Post

    projects.huffingtonpost.com/dying-to-be-free...

    Toby Fischer lives in South Dakota, where just 27 doctors are certified to prescribe buprenorphine -- a medication that blunts the symptoms of withdrawal from heroin and opioid painkillers. A Huffington Post analysis of government data found nearly half of all counties in America don't have such a certified physician. So every month, Fischer and his mother drive to Colorado to pick up their ...

  9. Not Enough Doctors Are Treating Heroin Addiction With A Life ...

    projects.huffingtonpost.com/dying-to-be-free...

    But just 31 percent of the 7,745 doctors in those areas are certified to treat the legal limit of 100 patients. Even in Vermont, where the governor in 2014 signed several bills adding $6.8 million in additional funding for medication-assisted treatment programs, only 28 percent or just 60 doctors are certified at the 100-patient level.