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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops. [7] [8] [6] It differs from the similarly named prednisone in having a hydroxyl at the 11th carbon instead of a ketone. Common side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue. [5]
It has no risk of liver damage. [2] [3] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). [2] [6] It has strong androgenic effects and weak anabolic effects, which make it useful for producing ...
Nonalcoholic fatty liver disease (NAFLD) is a silent condition that can affect anyone, regardless of age or lifestyle. According to the National Institute of Diabetes and Digestive and Kidney ...
Cardiovascular issues: AAS can negatively affect cholesterol levels and increase the risk of cardiovascular disease. Liver damage: Although drostanolone is not 17α-alkylated, high doses or prolonged use can still potentially damage the liver. Mood swings: AAS can cause aggression, irritability, and mood swings.
It can also cause liver damage. [5] [6] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). [5] [8] It has strong anabolic effects and weak androgenic effects. [5]
Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties. [36] [37] Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no substantial biological effects until converted via hepatic metabolism to prednisolone. [38]
In those with liver or kidney problems, extra care should be taken. [4] Spironolactone has not been well studied in pregnancy and should not be used to treat high blood pressure of pregnancy. [3] It is also a steroid that blocks the effects of the hormones aldosterone and, to a lesser degree, testosterone, causing some estrogen-like effects.