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Gout is due to persistently elevated levels of uric acid (urate) in the blood (hyperuricemia). [ 4 ] [ 7 ] This occurs from a combination of diet, other health problems, and genetic factors. [ 3 ] [ 4 ] At high levels, uric acid crystallizes and the crystals deposit in joints, tendons , and surrounding tissues, resulting in an attack of gout. [ 3 ]
Gout is a serious and painful form of arthritis that occurs when there is too much uric acid in the blood. “It is a very common form of arthritis,” says rheumatologist Dr. Orrin Troum. “Pain ...
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. [1]
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Colchicine is typically prescribed to mitigate or prevent the onset of gout, or its continuing symptoms and pain, using a low-dose prescription of 0.6 to 1.2 mg per day, or a high-dose amount of up to 4.8 mg in the first 6 hours of a gout episode. [13][25] With an oral dose of 0.6 mg, peak blood levels occur within one to two hours. [50] For ...
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