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D001806. LOINC. 6299-2, 59570-2, 12961-9, 12963-5, 12962-7. Blood urea nitrogen (BUN) is a medical test that measures the amount of urea nitrogen found in blood. The liver produces urea in the urea cycle as a waste product of the digestion of protein. Normal human adult blood should contain 7 to 18 mg/dL (0.388 to 1 mmol/L) of urea nitrogen. [1]
In medicine, the urea-to-creatinine ratio (UCR[1]), known in the United States as BUN-to-creatinine ratio, is the ratio of the blood levels of urea (BUN) (mmol/L) and creatinine (Cr) (μmol/L). BUN only reflects the nitrogen content of urea (MW 28) and urea measurement reflects the whole of the molecule (MW 60), urea is just over twice BUN (60/ ...
Calculated osmolarity = 2 Na + Glucose + Urea (all in mmol/L) As Na+ is the major extracellular cation, the sum of osmolarity of all other anions can be assumed to be equal to natremia, hence [Na+]x2 ≈ [Na+] + [anions] To calculate plasma osmolality use the following equation (typical in the US): = 2[Na +
v. t. e. Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry ...
The osmol gap is typically calculated with the following formula (all values in mmol/L): = = ([+] + [] + []) In non-SI laboratory units: Calculated osmolality = 2 x [Na mmol/L] + [glucose mg/dL] / 18 + [BUN mg/dL] / 2.8 + [ethanol/3.7] [3] (note: the values 18 and 2.8 convert mg/dL into mmol/L; the molecular weight of ethanol is 46, but empiric data shows that it does not act as an ideal ...
One mg/dL of creatinine equals 88.4 μmol/L. The typical human reference ranges for serum creatinine are 0.5 mg/dL to 1.0 mg/dL (about 45 μmol/L to 90 μmol/L) for women and 0.7 mg/dL to 1.2 mg/dL (60 μmol/L to 110 μmol/L) for men. The significance of a single creatinine value must be interpreted in light of the patient's muscle mass.
Urea: At high concentrations [>300 mg/dL(>50 mmol/L)]: headaches, vomiting, fatigue, carbamylation of proteins [2] Creatinine: Possibly affects glucose tolerance and erythrocyte survival [2] Cyanate: Drowsiness and hyperglycemia, carbamylation of proteins and altered protein function due to being a breakdown product of urea [2] Polyols (e.g ...
The structure of the molecule of urea is O=C(−NH 2) 2.The urea molecule is planar when in a solid crystal because of sp 2 hybridization of the N orbitals. [8] [9] It is non-planar with C 2 symmetry when in the gas phase [10] or in aqueous solution, [9] with C–N–H and H–N–H bond angles that are intermediate between the trigonal planar angle of 120° and the tetrahedral angle of 109.5°.