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Levacetylleucine. Levacetylleucine, sold under the brand name Aqneursa, is a medication used for the treatment of neurological manifestations of Niemann-Pick disease type C. [1][2] Levacetylleucine is a modified version of the amino acid leucine (N-Acetyl-L-Leucine). [1] It is taken by mouth.
Leucine (symbol Leu or L) [3] is an essential amino acid that is used in the biosynthesis of proteins.Leucine is an α-amino acid, meaning it contains an α-amino group (which is in the protonated −NH 3 + form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO − form under biological conditions), and a side chain isobutyl group, making it a non ...
β-Hydroxy β-methylbutyric acid [note 1] (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS.
A branched-chain amino acid (BCAA) is an amino acid having an aliphatic side-chain with a branch (a central carbon atom bound to three or more carbon atoms). Among the proteinogenic amino acids, there are three BCAAs: leucine, isoleucine, and valine. [1] Non-proteinogenic BCAAs include 2-aminoisobutyric acid and alloisoleucine.
Niemann–Pick type C (NPC) (colloquially, "Childhood Alzheimer's " [2]) is a lysosomal storage disease associated with mutations in NPC1 and NPC2 genes. Niemann–Pick type C affects an estimated 1:150,000 people. [3] Approximately 50% of cases present before ten years of age, but manifestations may first be recognized as late as the sixth decade.
The endogenous α-amino acids L-leucine and L-isoleucine, which closely resemble the gabapentinoids in chemical structure, are apparent ligands of the α 2 δ VDCC subunit with similar affinity as gabapentin and pregabalin (e.g., IC 50 = 71 nM for L-isoleucine), and are present in human cerebrospinal fluid at micromolar concentrations (e.g., 12 ...
The endogenous α-amino acids L-leucine and L-isoleucine, which closely resemble pregabalin and the other gabapentinoids in chemical structure, are apparent ligands of the α 2 δ VDCC subunit with similar affinity as the gabapentinoids (e.g., IC 50 =71 nM for L-isoleucine), and are present in human cerebrospinal fluid at micromolar ...
Infobox references. β-Leucine (beta-leucine) is a beta amino acid and positional isomer of L -leucine which is naturally produced in humans via the metabolism of L -leucine by the enzyme leucine 2,3-aminomutase. [1][2][3] In cobalamin (vitamin B 12) deficient individuals, plasma concentrations of β-leucine are elevated. [3]
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