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TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. [5]
TBK1 may refer to: TANK-binding kinase 1, an enzyme; IkappaB kinase, an enzyme This page was last edited on 30 December 2019, at 15:16 (UTC). Text is available under ...
Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. [17] Mutations in IKK-α in humans have been linked to lethal fetal malformations. [18]
Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD (TANK-binding kinase 1-binding protein 1) can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD .
Protein tyrosine kinase 6 (PTK6) Tyr215, Tyr315 and Tyr326: Activates Akt in response to epidermal growth factor (EGF) [19] TANK-binding kinase 1 (TBK1) Thr195, Ser378 and Ser473: In response to Toll-like receptor activation in macrophages. [20] DNA-dependent protein kinase (DNA-PK) Ser473: Activated by double-strand DNA breaks formed by ...
TRAM-TRIF signals activate the ubiquitin ligase TRAF3 followed by the activation of non-canonical IKK kinases: TANK binding kinase 1 (TBK1) and IKKε. TBK1 phosphorylates the pLxIS consensus motif of TRIF that is necessary to recruit interferon regulatory factor (IRF) 3.
106763 Ensembl ENSG00000146216 ENSMUSG00000015599 UniProt Q5TCY1 Q6PCN3 RefSeq (mRNA) NM_032538 NM_001162864 NM_175351 RefSeq (protein) NP_115927 NP_001156336 Location (UCSC) Chr 6: 43.24 – 43.29 Mb Chr 17: 46.75 – 46.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tau tubulin kinase 1 is a protein that in humans is encoded by the TTBK1 gene. References ^ a b c GRCh38: Ensembl ...
Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. [11] The small-molecule inhibitor of IKK-β SAR113945, developed by Sanofi-Aventis, was evaluated in patients with knee osteoarthritis. [11 ...